Received: May 26, 2026 / Accepted: Sep 05, 2026 / Published: Oct 31, 2026
Magoderna subresinosum is a medicinal mushroom with potential biological activities; however, information on polysaccharides from its fruiting bodies remains limited. This study aimed to evaluate the total polysaccharide content, antioxidant activity, and anti-inflammatory potential of polysaccharide extracts from the fruiting bodies of two M. subresinosum strains, Am6 and Am32, using commercial Ganoderma lucidum strain DT as a reference. Total polysaccharide content was quantified using a D-glucose standard curve and expressed as mg GE/g dry extract. Antioxidant and anti-inflammatory activities were evaluated using the ABTS+ radical-scavenging assay and the bovine serum albumin (BSA) denaturation assay, respectively. The polysaccharide extraction yields were 11.43% and 12.23% for strains Am6 and Am32, respectively, compared with 10.24% for strain DT. Am32 showed the highest total polysaccharide content, reaching 700.08 ± 36.98 mg GE g-1 dry extract, which was significantly higher than those of strain Am6 and DT. Both M. subresinosum extracts exhibited concentration-dependent ABTS+ radical-scavenging activity, although their IC50 values were higher than those of G. lucidum strain DT and ascorbic acid. In the BSA denaturation assay, the PS extract of M. subresinosum strain Am32 exhibited the strongest anti-inflammatory activity, showing greater inhibitory activity than the PS extract of G. lucidum strain DT. These findings suggest that the fruiting bodies of M. subresinosum are an abundant source of polysaccharides with antioxidant and anti-inflammatory potential. Further studies on the composition, molecular structure, and mechanisms of action are needed to clarify the bioactive properties of polysaccharide compounds from this mushroom species.
