Received: Nov 01, 2025 / Accepted: Dec 30, 2025 / Published: Dec 31, 2025
Saccharomyces cerevisiae is considered to be an alternative to antibiotics in reducing the growth of pathogenic bacteria and enhancing the mucosal immune system. In countries with developed livestock industries, antibiotic resistance of Salmonella pullorum is still causing difficulties in controlling Pullorum disease. This study aimed to isolate and select S. cerevisiae strains with antagonistic activity against S. pullorum for potential application in probiotics production. A total of eight S. cerevisiae strains were isolated from 50 ripe mango samples. All the isolated strains exhibited inhibitory effects against S. pullorum. Among them, strains SC1, SC6, and SC8 showed strong antagonism, with inhibition zone diameters of 16 ± 0.87mm, 16 ± 0.50mm, and 17 ± 1.80mm, respectively. These isolates exhibited high stability under various conditions. These findings suggest that S. cerevisiae strains SC1, SC6, and SC8 are potential candidates for producing a probiotic to control poultry diseases.
